Haspin Kinase

Related Products

Haspin is a protein kinase that regulates chromosome and spindle function during mitosis and meiosis. Haspin expression is detected in fetal liver, skin, kidney, small intestine and in all proliferating cells. Haspin phosphorylates H3 thr3 (H3T3ph) in human cell lines and depletion of Haspin by RNA interference reveals that Haspin is required for H3 thr3 phosphorylation in mitotic cells. Phosphorylation of H3T3ph by Haspin is necessary for chromosomal passenger complex (CPC) accumulation at centromeres. H3T3ph then positions the CPC at centromeres to regulate selected targets of Aurora B during mitosis.

Haspin Kinase Inhibitors (12)

Haspin Kinase Related Products (12):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-15217

CHR-6494	Inhibitor	98.07%
CHR-6494 is a potent inhibitor of haspin, with an IC₅₀ of 2 nM. CHR-6494 inhibits histone H3T3 phosphorylation. CHR-6494 can be used in the research of cancer.

HY-13455

LDN-192960	Inhibitor	99.56%
LDN-192960 is an inhibitor of Haspin and Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) with IC₅₀s of 10 nM and 48 nM, respectively.

HY-146636

Haspin-IN-3	Inhibitor	98.14%
Haspin-IN-3 (compound 8l) is a potent haspin inhibitor with IC₅₀ of 14 nM. Haspin-IN-3 has anticancer effects.

HY-110320

LDN-209929 dihydrochloride	Inhibitor	≥99.0%
LDN-209929 dihydrochloride is a potent and selective haspin kinase inhibitor (IC₅₀=55 nM) with180-fold selectivity verses DYRK2 (IC₅₀=9.9 μM). LDN-209929 is a optimized analogue of LDN-192960 (HY-13455).

HY-13455A

LDN-192960 hydrochloride	Inhibitor	99.78%
LDN-192960 hydrochloride is an inhibitor of Haspin and Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) with IC₅₀s of 10 nM and 48 nM, respectively.

HY-163858

Haspin-IN-4	Inhibitor
Haspin-IN-4 (Compound 60) is a selective inhibitor of Haspin with an IC₅₀ value of 0.01 nM. Haspin-IN-4 possesses anticancer activity and can be used in cancer research.

HY-135002

LDN-209929	Inhibitor
LDN-209929 is a potent haspin kinase inhibitor, with IC₅₀ values of 55 nM and 9.9 μM for Haspin and DYRK2, respectively.

HY-100368

MELK-8a	Inhibitor
MELK-8a (NVS-MELK8a) is a highly potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor with IC₅₀ of 2 nM. MELK-8a also inhibits Flt3 (ITD), Haspin, PDGFRα with IC₅₀s of 0.18, 0.19, and 0.42 μM, respectively. MELK plays an essential role in regulating cell mitosis in a subset of cancer cells.

HY-155341

HSK205	Inhibitor
HSK205 is a dual FLT3 and haspin inhibitor, with IC₅₀ of 0.187 nM for FLT3. HSK205 has antitumor activity.

HY-146587

Haspin-IN-2	Inhibitor
Haspin-IN-2 (compound 4) is a potent and selective haspin inhibitor with an IC₅₀ of 50 nM. Haspin-IN-1 also inbibits CLK1 and DYRK1A with IC₅₀s of 445 nM and 917 nM, respectively.

HY-146586

Haspin-IN-1	Inhibitor
Haspin-IN-1 (compound 2a) is a haspin inhibitor with an IC₅₀ of 119 nM. Haspin-IN-1 also inbibits CLK1 and DYRK1A with IC₅₀s of 221 nM and 916.3 nM, respectively.

HY-110350

CHR-6494 TFA	Inhibitor
CHR-6494 TFA is a potent inhibitor of haspin, with an IC₅₀ of 2 nM. CHR-6494 TFA inhibits histone H3T3 phosphorylation. CHR-6494 TFA induces the apoptosis of cancer cells, including melanoma and breast cancer. CHR-6494 TFA can be used in the research of cancer.

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